Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy

@article{DellOrco2009CalciumBS,
  title={Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy},
  author={Daniele Dell'Orco and Petra Behnen and Sara Linse and Karl-Wilhelm Koch},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={67},
  pages={973-984}
}
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca2+ sensor (NCS) that regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in photoreceptors. In this study, we investigated the Ca2+-induced effects on the conformation and the thermal stability of four GCAP1 variants associated with hereditary human cone dystrophies. Ca2+ binding stabilized the conformation of all the GCAP1 variants independent of myristoylation. The myristoylated wild-type GCAP1 was found to… CONTINUE READING

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