Calcium antagonists and the "stunned" myocardium.

@article{Nayler1990CalciumAA,
  title={Calcium antagonists and the "stunned" myocardium.},
  author={W J Nayler and Daniel J. Buckley and John Leong},
  journal={Cardioscience},
  year={1990},
  volume={1 1},
  pages={61-4}
}
Hearts which are made ischemic for relatively short periods of time, and then re-perfused, exhibit a temporary decline in tension-generating activity but are not irreversibly injured". Experiments were undertaken to find out whether such "stunned" hearts develop a perfusion defect, and whether chemically heterogeneous Ca(2+)-antagonists provide protection, when used prophylatically. "Stunning" was produced by repetitive 10 minute episodes of ischemia, followed by 15 minutes of reperfusion. The… CONTINUE READING

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