Calcium antagonist prevents calcium flux induced necrosis and apoptosis in ischemic reperfusion of rat liver

@article{Chattopadhyay2008CalciumAP,
  title={Calcium antagonist prevents calcium flux induced necrosis and apoptosis in ischemic reperfusion of rat liver},
  author={Pronobesh Chattopadhyay and Nevneet Verma and Anurag Verma and Gunjan Shukla and Arun Kumar Wahi},
  journal={Indian Journal of Clinical Biochemistry},
  year={2008},
  volume={23},
  pages={356-360}
}
Ca2+ accumulation in mitochondria is responsible for the cell abnormality associated with ischemia and reperfusion injury. The present study was aimed to evaluate the efficacy of Ca2+ channel blocker- amlodipine on the mitochondrial Ca2+ accumulation in ischemic and reperfusion (I/R) induced liver injury. Eighteen wistar rats were divided in sham-operated control group-I (n = 6), ischemia and reperfusion group-II (n = 6) and amlodipine treated group-III (1 mg/kg body weight /daily by oral route… CONTINUE READING