Calcium antagonist clevidipine reduces myocardial reperfusion injury by a mechanism related to bradykinin and nitric oxide.

@article{Gourine2002CalciumAC,
  title={Calcium antagonist clevidipine reduces myocardial reperfusion injury by a mechanism related to bradykinin and nitric oxide.},
  author={Andrey V. Gourine and John Pernow and Dmitry M Poputnikov and Per-Ove Sj{\"o}quist},
  journal={Journal of cardiovascular pharmacology},
  year={2002},
  volume={40 4},
  pages={564-70}
}
Certain calcium antagonists, in addition to their classic actions, can increase blood flow during ischemia via bradykinin- and nitric oxide (NO)-dependent mechanisms and protect the ischemic myocardium against reperfusion injury by enhancing NO bioavailability. The current study aimed to investigate the possible involvement of bradykinin and NO in the cardioprotective action of the short-acting calcium antagonist clevidipine during late ischemia and reperfusion. Anesthetized pigs were subjected… CONTINUE READING
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