Calcium antagonism of an opiate drug effect on an excitable cell membrane.

@article{Rohani1983CalciumAO,
  title={Calcium antagonism of an opiate drug effect on an excitable cell membrane.},
  author={Farzan Rohani and G. B. Frank},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1983},
  volume={224 2},
  pages={459-65}
}
When frog sartorius muscles are exposed to methadone (2-4 X 10(-4) M) the action potential recorded intracellularly is depressed and eliminated in 3 to 4 hr. This is due to a decrease in the sodium conductance as measured by the maximum rate of rise of the action potential. When the calcium concentration in frog Ringer's solution (normally 1.08 mM) was… CONTINUE READING