Calcium- and voltage-activated plateau currents of cardiac Purkinje fibers

@article{Kenyon1987CalciumAV,
  title={Calcium- and voltage-activated plateau currents of cardiac Purkinje fibers},
  author={James L. Kenyon and John L. Sutko},
  journal={The Journal of General Physiology},
  year={1987},
  volume={89},
  pages={921 - 958}
}
We have used the two-microelectrode voltage-clamp technique to investigate the components of membrane current that contribute to the formation of the early part of the plateau phase of the action potential of calf cardiac Purkinje fibers. 3,4-Diaminopyridine (50 microM) reduced the net transient outward current elicited by depolarizations to potentials positive to -30 mV but had no consistent effect on contraction. We attribute this effect to the blockade of a voltage-activated transient… CONTINUE READING
22 Extracted Citations
43 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 43 references

membrane currents in calf Purkinje fibres

  • E. Marban, W. G. Wier
  • Journal ofPhysiology
  • 1985
Highly Influential
9 Excerpts

Ionic basis of ryanodine-sensitive currents in cardiac

  • Kenyon, L J., J . L . Sutko
  • 1986

Ryanodine and aminopyridine sensitive currents of cardiac Purkinje fibers

  • J. L. Kenyon, J. L. Sutko
  • Biophysical journal .
  • 1986

A model of cardiac electrical activity incorporating ionic pumps and concentration changes

  • K. Peper, R. Riidel, W. Trautwein
  • Philosophical Transactions of the Royal Society…
  • 1985

Similar Papers

Loading similar papers…