Calcium and the replication of human vascular smooth muscle cells: studies on the activation and translocation of extracellular signal regulated kinase (ERK) and cyclin D1 expression.

@article{Shukla2005CalciumAT,
  title={Calcium and the replication of human vascular smooth muscle cells: studies on the activation and translocation of extracellular signal regulated kinase (ERK) and cyclin D1 expression.},
  author={Nitin C. Shukla and Daniel Rowe and Jane M. Hinton and Gianni Angelini and Jamie Yancey Jeremy},
  journal={European journal of pharmacology},
  year={2005},
  volume={509 1},
  pages={
          21-30
        }
}
Since the precise role of sarcoplasmic reticular Ca2+ in mediating vascular smooth muscle cells (VSMC) proliferation is unknown, the effect of pre-incubation with thapsigargin on extracellular signal regulated kinase (ERK) activation, the translocation of activated of ERK 1/2 to the nucleus, cyclin D1 expression, the onset of S phase and cytosolic Ca2+ levels were studied. Human saphenous vein VSMCs (hVSMC) were incubated with 10 nM thapsigargin for 24 h followed by stimulation with fetal calf… CONTINUE READING
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