Calcium and the damage pathways in muscular dystrophy.

@article{Allen2010CalciumAT,
  title={Calcium and the damage pathways in muscular dystrophy.},
  author={David G. Allen and Othon L. Gervasio and Ella W. Yeung and N. Peter Whitehead},
  journal={Canadian journal of physiology and pharmacology},
  year={2010},
  volume={88 2},
  pages={
          83-91
        }
}
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by the absence of the cytoskeletal protein dystrophin. Experiments on the mdx mouse, a model of DMD, have shown that mdx muscles are particularly susceptible to stretch-induced damage. In this review, we discuss evidence showing that a series of stretched contractions of mdx muscle fibres causes a prolonged increase in resting intracellular calcium concentration ([Ca2+]i). The rise in [Ca2+]i is caused by Ca2+ entry… CONTINUE READING
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