Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex.

Abstract

Excitotoxic cell death (ECD) is characteristic of mammalian brain following min of anoxia, but is not observed in the western painted turtle following days to months without oxygen. A key event in ECD is a massive increase in intracellular Ca(2+) by over-stimulation of N-methyl-d-aspartate receptors (NMDARs). The turtle's anoxia tolerance may involve the… (More)

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@article{Shin2005CalciumAP, title={Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex.}, author={Damian Seung-ho Shin and Michael Patrick Wilkie and Matthew Edward Pamenter and Leslie T Buck}, journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology}, year={2005}, volume={142 1}, pages={50-7} }