Calcium and mitochondria in the regulation of cell death.

  title={Calcium and mitochondria in the regulation of cell death.},
  author={Sten Orrenius and Vladimir Gogvadze and Boris Zhivotovsky},
  journal={Biochemical and biophysical research communications},
  volume={460 1},
The calcium ion has long been known to play an important role in cell death regulation. Hence, necrotic cell death was early associated with intracellular Ca(2+) overload, leading to mitochondrial permeability transition and functional collapse. Subsequent characterization of the signaling pathways in apoptosis revealed that Ca(2+)/calpain was critically involved in the processing of the mitochondrially localized, Apoptosis Inducing Factor. More recently, the calcium ion has been demonstrated… CONTINUE READING
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