Calcium and endoplasmic reticulum-mitochondria tethering in neurodegeneration.

  title={Calcium and endoplasmic reticulum-mitochondria tethering in neurodegeneration.},
  author={Tito Cal{\`i} and Denis Ottolini and Marisa Brini},
  journal={DNA and cell biology},
  volume={32 4},
Mitochondria are key players of many physiological processes and deregulation of mitochondrial and/or mitochondria-related activity is unequivocally associated to numerous ageing-linked neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Recently, the endoplasmic reticulum (ER) stress condition is emerging as a common feature relevant to the pathogenesis of this type of diseases. Mitochondria and ER are two… CONTINUE READING
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