Calcium and depolarization dependence of twin-pulse facilitation of synaptic release at nerve terminals of crayfish and frog muscle

@article{Dudel1989CalciumAD,
  title={Calcium and depolarization dependence of twin-pulse facilitation of synaptic release at nerve terminals of crayfish and frog muscle},
  author={Josef Dudel},
  journal={Pfl{\"u}gers Archiv},
  year={1989},
  volume={415},
  pages={304-309}
}
Transmitter quanta were elicited from nerve terminals of crayfish and frog muscle by depolarization pulses through a macro-patch-clamp electrode. The rates of quantal release for twin pulses and their ratio, twin pulse facilitation, Fd, were determined. When the electrode was perfused with normal Cae (13.5 mM for crayfish, 1.8 mM for frog), Fd was low for threshold depolarizations, increased to a maximum at medium depolarizations, decreased when the rate of release due to the first pulse… CONTINUE READING
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Calcium dependence ofpresynaptic calcium current and post-synaptie response at the squid giant synapse

  • G JAugustine, MP Charlton
  • J Physiol (Lond)
  • 1986

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