Calcium and cell death signaling in neurodegeneration and aging.

@article{Smaili2009CalciumAC,
  title={Calcium and cell death signaling in neurodegeneration and aging.},
  author={Soraya Soubhi Smaili and Hanako Hirata and Rodrigo Ureshino and Priscila Totarelli Monteforte and A. Pimentel Morales and Mari L Muler and Juliana Yoshie Terashima and Karen Tubono Oseki and Tatiana R Rosenstock and Guiomar Silva Lopes and Cl{\'a}udia Bincoletto},
  journal={Anais da Academia Brasileira de Ciencias},
  year={2009},
  volume={81 3},
  pages={
          467-75
        }
}
Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative stress and cell death. Several events are related to the increase in Ca m2+, including regulation and activation of a number of Ca2+ dependent enzymes, such as phospholipases, proteases and nucleases. Mitochondria and endoplasmic reticulum (ER) play pivotal roles in the… CONTINUE READING

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