Calcium and cAMP Levels Interact to Determine Attraction versus Repulsion in Axon Guidance

@article{Forbes2012CalciumAC,
  title={Calcium and cAMP Levels Interact to Determine Attraction versus Repulsion in Axon Guidance},
  author={Elizabeth M. Forbes and Andrew W. Thompson and Jiajia Yuan and Geoffrey J. Goodhill},
  journal={Neuron},
  year={2012},
  volume={74},
  pages={490-503}
}
Correct guidance of axons to their targets depends on an intricate network of signaling molecules in the growth cone. Calcium and cAMP are two key regulators of whether axons are attracted or repelled by molecular gradients, but how these molecules interact to determine guidance responses remains unclear. Here, we constructed a mathematical model for the relevant signaling network, which explained a large range of previous biological data and made predictions for when axons will be attracted or… CONTINUE READING
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