Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

@article{Pinton2008CalciumAA,
  title={Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis},
  author={Paolo Pinton and Carlotta Giorgi and Roberta Siviero and Erika Zecchini and Rosario Rizzuto},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={6407-6418}
}
There is a growing consensus that the various forms of cell death (necrosis, apoptosis and autophagy) are not separated by strict boundaries, but rather share molecular effectors and signaling routes. Among the latter, a clear role is played by calcium (Ca2+), the ubiquitous second messenger involved in the control of a broad variety of physiological events. Fine tuning of intracellular Ca2+ homeostasis by anti- and proapoptotic proteins shapes the Ca2+ signal to which mitochondria and other… CONTINUE READING
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