Calcium and acid rebound: a reappraisal.

@article{Hade1992CalciumAA,
  title={Calcium and acid rebound: a reappraisal.},
  author={Joel E. Hade and Howard M. Spiro},
  journal={Journal of clinical gastroenterology},
  year={1992},
  volume={15 1},
  pages={
          37-44
        }
}
We review acid rebound, the seemingly paradoxical increase in acid secretion resulting from administration of an antacid. Primarily a laboratory observation, the demonstration of the phenomenon was a major contributing factor to the swift, and possibly unjustified, fall from grace of calcium carbonate in the therapy of peptic ulcer disease despite years of apparently successful use. Calcium, as carbonate or other salts, causes an increase in gastric acid secretion owing, at least in part, to… 
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