Calcium-activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments.

@article{Waton1995CalciumactivatedPI,
  title={Calcium-activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments.},
  author={P H Waton and Shane T. Mortimer and Kenneth Kezhi Wang and Dorothy E. Croall and David Arthur Hanley},
  journal={Journal of molecular endocrinology},
  year={1995},
  volume={15 1},
  pages={61-71}
}
Our studies suggest that protein kinase C is involved in low calcium (Ca2+)-stimulated secretion of parathyroid hormone (PTH) but not directly in high Ca(2+)-stimulated intracellular degradation of PTH to secreted carboxyl-terminal fragments (C-PTH), an important component of Ca(2+)-regulated PTH secretion. The present study was undertaken to determine the… CONTINUE READING