Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology

@article{Grissmer1993CalciumactivatedPC,
  title={Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology},
  author={Stephan Grissmer and Aaron Ngocky Nguyen and Michael D Cahalan},
  journal={The Journal of General Physiology},
  year={1993},
  volume={102},
  pages={601 - 630}
}
Ca(2+)-activated K+[K(Ca)] channels in resting and activated human peripheral blood T lymphocytes were characterized using simultaneous patch-clamp recording and fura-2 monitoring of cytosolic Ca2+ concentration, [Ca2+]i. Whole-cell experiments, using EGTA-buffered pipette solutions to raise [Ca2+]i to 1 microM, revealed a 25-fold increase in the number of conducting K(Ca) channels per cell, from an average of 20 in resting T cells to > 500 channels per cell in T cell blasts after mitogenic… CONTINUE READING
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Diverse K+ channels in primary human T lymphocytes

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