Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest.

@article{Feng2008CalciumactivatedPC,
  title={Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest.},
  author={Jun Feng and Yuhong Liu and Richard T. Clements and Neel R. Sodha and Kamal R. Khabbaz and Venkatachalam Senthilnathan and Katherine Keiko Nishimura and Seth L Alper and Frank W Sellke},
  journal={Circulation},
  year={2008},
  volume={118 14 Suppl},
  pages={S46-51}
}
BACKGROUND Cardioplegic arrest (CP) followed by reperfusion after cardiopulmonary bypass induces coronary microvascular dysfunction. We investigated the role of calcium-activated potassium (K(Ca)) channels in this dysfunction in the human coronary microvasculature. METHODS AND RESULTS Human atrial tissue was harvested before CP from a nonischemic segment and after CP from an atrial segment exposed to hyperkalemic cold blood CP (mean CP time, 58 minutes) followed by 10-minute reperfusion. In… CONTINUE READING