Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.

  title={Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.},
  author={Ralph A. Nixon and Kyoshi Saito and Frida Grynspan and William R. Griffin and Shigeru Katayama and Toshiyuki Honda and Panaiyur S. Mohan and Thomas B. Shea and Mary Lou Beermann},
  journal={Annals of the New York Academy of Sciences},
Calpains (CANPs) are a family of calcium-dependent cysteine proteases under complex cellular regulation. By making selective limited proteolytic cleavages, they activate or alter the regulation of certain enzymes, including key protein kinases and phosphatases, and induce specific cytoskeletal rearrangements, accounting for their suspected involvement in intracellular signaling, vesicular trafficking, and structural stabilization. Calpain activity has been implicated in various aging phenomena… CONTINUE READING


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