Calcium-activated chloride currents in primary cultures of rabbit distal convoluted tubule.

@article{Bidet1996CalciumactivatedCC,
  title={Calcium-activated chloride currents in primary cultures of rabbit distal convoluted tubule.},
  author={Michel Bidet and Michel Tauc and Isabelle Rubera and Gabriella De Renzis and Chantal Poujeol and Marie Th{\'e}r{\`e}se Bohn and Philippe Poujeol},
  journal={The American journal of physiology},
  year={1996},
  volume={271 4 Pt 2},
  pages={F940-50}
}
Chloride (Cl-) conductances were studied in primary cultures of rabbit distal convoluted tubule (very early distal "bright" convoluted tubule, DCTb) by the whole cell patch-clamp technique. We identified a Cl- current activated by 2 microM extracellular ionomycin. The kinetics of the macroscopic current were time dependent for depolarizing potentials with a slow developing component. The steady state current presented outward rectification, and the ion selectivity sequence was I- > Br- > > Cl… CONTINUE READING
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