Calcium-activated chloride conductance in frog olfactory cilia.

  title={Calcium-activated chloride conductance in frog olfactory cilia.},
  author={Steven J. Kleene and Robert C. Gesteland},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={11 11},
We have measured the effects of cytoplasmic Ca2+ on the conductance of single cilia excised from frog olfactory receptor neurons. When free cytoplasmic Ca2+ is buffered at 0.1 microM, ciliary conductance is low. As Ca2+ is increased, ciliary conductance increases. Maximal conductance averages sevenfold higher than that measured in the absence of Ca2+. We estimate that the K1/2 for Ca2+ activation is 5 microM; the dose-response curve indicates some positive cooperativity of Ca2+ binding… CONTINUE READING
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