Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.

@article{Huang2010CalciumactivatedCI,
  title={Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.},
  author={Chang-jiang Huang and Tatyana Gurlo and Leena Haataja and Safia Costes and Marie C{\'e}cile Daval and Sergey Vasilyevich Ryazantsev and Xiuji Wu and Alexandra E Butler and Peter C Butler},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 1},
  pages={339-48}
}
The islet in type 2 diabetes (T2DM) and the brain in neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (IAPP) in T2DM). Excessive activation of the Ca(2+)-sensitive protease calpain-2 has been implicated as a mediator of oligomer-induced cell death and dysfunction in neurodegenerative diseases. To establish if human IAPP toxicity is mediated by a comparable mechanism, we… CONTINUE READING

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