Calcium accelerates endocytosis of vSNAREs at hippocampal synapses

@article{Sankaranarayanan2001CalciumAE,
  title={Calcium accelerates endocytosis of vSNAREs at hippocampal synapses},
  author={Sethuraman Sankaranarayanan and Timothy A Ryan},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={129-136}
}
A pH-sensitive form of green-fluorescent protein (GFP) fused to the lumenal domain of VAMP (synapto-pHluorin) provides a sensitive optical probe to track the net balance between exocytosis and endocytosis of this protein at small synaptic terminals of the central nervous system. Here we used a reversible proton-pump blocker that prevents vesicle re-acidification upon endocytosis to trap vesicles in the alkaline state during recycling. In combination with optical measurements of synapto-pHluorin… CONTINUE READING
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