Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.

  title={Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.},
  author={Matthias Dewenter and Albert H von der Lieth and Hugo A. Katus and Johannes Backs},
  journal={Circulation research},
  volume={121 8},
Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes, Ca2+ is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation-transcription coupling. Disturbances in cellular Ca2+-handling and alterations in Ca2+-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcription coupling… CONTINUE READING
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