Calcium Signaling

  title={Calcium Signaling},
  author={David E. Clapham},

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Fundamentals of Cellular Calcium Signaling: A Primer.

This primer discusses basic principles and mechanisms underlying cellular Ca2+ signaling andCa2+ homeostasis, with particular focus on Ca2- stores and Ca1+ transport across cellular membranes, as well as mechanisms by which Ca2+.

Calcium Signaling Proteins in Human Diseases and their Potential as Drug Targets

The calcium (Ca2+) signaling proteins are activated by a transient increase in free resting intracellular free Ca2+ concentration and regulate numerous cell process including disease conditions and have the potential as drug targets.

Lessons from the Endoplasmic Reticulum Ca2+ Transporters—A Cancer Connection

The mechanisms of activation and functional regulation of ER Ca2+ transporters in the establishment ofCa2+ homeostasis are explored, and the aberrant alterations of these transporators in carcinogenesis are contextualized, presenting Ca2-based therapeutic interventions as a means to tackle malignancies.

Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels.

This review describes how Ca2+ microdomains generated by store-operated calcium channels, a widespread and conservedCa2+ entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca2- microdomain can be influenced by Ca2 + ATPase pumps are influenced.

Mitochondrial Ca2+ Signaling in Health, Disease and Therapy

This review summarizes the current knowledge on the regulation of m Ca2+ homeostasis, the related mechanisms and the significance of this regulation in physiology and human diseases and highlights strategies aimed at remedying mCa2+ dysregulation as promising therapeutical approaches.

Cell death as a result of calcium signaling modulation: a cancer-centric prospective.

Exploiting Cameleon Probes to Investigate Organelles Ca2+ Handling.

The usage of Förster resonance energy transfer (FRET)-based Cameleon probes to investigate Ca2+ influx across the plasma membrane (PM) orCa2+ release from the main intracellular Ca2+, the endoplasmic reticulum (ER), is described.

Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer’s Disease

The present review summarizes the cellular and molecular mechanism underlying Ca2+ signaling regulation and Ca1+ homeostasis maintenance at ER and mitochondria levels, focusing on Alzheimer’s disease.

Ca2+ signals in plant immunity

Recent work that has both shed light on and deepened the mysteries of Ca2+ signaling in plant immunity is discussed.



Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.

A role for mitochondria is demonstrated in controlling Ca(2+) channel activity and signal transmission from the plasma membrane to the nucleus and inhibiting nuclear translocation of the transcription factor NFAT in parallel with CRAC channel activity.

Annexins: linking Ca2+ signalling to membrane dynamics

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels. A unique class of these proteins — annexins — can bind to certain

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling

Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neurons, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+.

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Redox active calcium ion channels and cell death.

  • P. Waring
  • Biology
    Archives of biochemistry and biophysics
  • 2005

ER-mitochondria communication. How privileged?

This work has shown that mitochondria have privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

The molecular choreography of a store-operated calcium channel

New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.

Store depletion and calcium influx.

The electrophysiological properties of the prototype store-operated current ICRAC are focused on, the regulatory mechanisms that control it are discussed, and recent advances toward the identification of molecular mechanisms involved in this ubiquitous and important Ca2+ entry pathway are considered.

The mitochondrial calcium uniporter is a highly selective ion channel

By patch-clamping the inner mitochondrial membrane, it is concluded that the properties of the current mediated by this novel channel are those of the MCU, enabling high Ca2+ selectivity despite relatively low cytoplasmic Ca 2+ concentrations.