Calcium Signaling

@article{Clapham2007CalciumS,
  title={Calcium Signaling},
  author={David E. Clapham},
  journal={Cell},
  year={2007},
  volume={131},
  pages={1047-1058}
}
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References

SHOWING 1-10 OF 76 REFERENCES

Lymphocyte calcium signaling from membrane to nucleus

Studies of the pathways that allow Ca2+ entry, the function of Ca2 + in the regulation of cell polarity and motility and the principles by which Ca2-dependent transcription regulates lymphocyte function are reviewed.

Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.

A role for mitochondria is demonstrated in controlling Ca(2+) channel activity and signal transmission from the plasma membrane to the nucleus and inhibiting nuclear translocation of the transcription factor NFAT in parallel with CRAC channel activity.

Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells.

Annexins: linking Ca2+ signalling to membrane dynamics

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels. A unique class of these proteins — annexins — can bind to certain…

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling

Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neurons, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+.

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Redox active calcium ion channels and cell death.

  • P. Waring
  • Biology
    Archives of biochemistry and biophysics
  • 2005

ER-mitochondria communication. How privileged?

This work has shown that mitochondria have privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

The molecular choreography of a store-operated calcium channel

New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.
...