Calcium Signaling

  title={Calcium Signaling},
  author={David E. Clapham},

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Fundamentals of Cellular Calcium Signaling: A Primer.

This primer discusses basic principles and mechanisms underlying cellular Ca2+ signaling andCa2+ homeostasis, with particular focus on Ca2- stores and Ca1+ transport across cellular membranes, as well as mechanisms by which Ca2+.

Calcium Signaling: A Communication Network that Regulates Cellular Processes

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Calcium signaling is involved in diverse cellular processes in fungi

The evolutionary aspects of Ca2+ signalling and cell functions of major Ca 2+ signalling proteins in different fungi are described and the roles of prokaryotes and eukaryotes in the signalling process are described.

Calcium Signaling Proteins in Human Diseases and their Potential as Drug Targets

The calcium (Ca2+) signaling proteins are activated by a transient increase in free resting intracellular free Ca2+ concentration and regulate numerous cell process including disease conditions and have the potential as drug targets.

Lessons from the Endoplasmic Reticulum Ca2+ Transporters—A Cancer Connection

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Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels.

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Mitochondrial Ca2+ Signaling in Health, Disease and Therapy

This review summarizes the current knowledge on the regulation of m Ca2+ homeostasis, the related mechanisms and the significance of this regulation in physiology and human diseases and highlights strategies aimed at remedying mCa2+ dysregulation as promising therapeutical approaches.

Cell death as a result of calcium signaling modulation: a cancer-centric prospective.

Exploiting Cameleon Probes to Investigate Organelles Ca2+ Handling.

The usage of Förster resonance energy transfer (FRET)-based Cameleon probes to investigate Ca2+ influx across the plasma membrane (PM) orCa2+ release from the main intracellular Ca2+, the endoplasmic reticulum (ER), is described.



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Studies of the pathways that allow Ca2+ entry, the function of Ca2 + in the regulation of cell polarity and motility and the principles by which Ca2-dependent transcription regulates lymphocyte function are reviewed.

Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.

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Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells.

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Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neurons, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+.

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Redox active calcium ion channels and cell death.

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  • Biology
    Archives of biochemistry and biophysics
  • 2005

ER-mitochondria communication. How privileged?

This work has shown that mitochondria have privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

The molecular choreography of a store-operated calcium channel

New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.