Calcium Signaling

@article{Clapham2007CalciumS,
  title={Calcium Signaling},
  author={David E. Clapham},
  journal={Cell},
  year={2007},
  volume={131},
  pages={1047-1058}
}

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References

SHOWING 1-10 OF 76 REFERENCES

Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.

A role for mitochondria is demonstrated in controlling Ca(2+) channel activity and signal transmission from the plasma membrane to the nucleus and inhibiting nuclear translocation of the transcription factor NFAT in parallel with CRAC channel activity.

Annexins: linking Ca2+ signalling to membrane dynamics

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels. A unique class of these proteins — annexins — can bind to certain

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling

Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neurons, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+.

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

Integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

Redox active calcium ion channels and cell death.

  • P. Waring
  • Biology
    Archives of biochemistry and biophysics
  • 2005

ER-mitochondria communication. How privileged?

This work has shown that mitochondria have privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

The molecular choreography of a store-operated calcium channel

New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.

Store depletion and calcium influx.

The electrophysiological properties of the prototype store-operated current ICRAC are focused on, the regulatory mechanisms that control it are discussed, and recent advances toward the identification of molecular mechanisms involved in this ubiquitous and important Ca2+ entry pathway are considered.

The mitochondrial calcium uniporter is a highly selective ion channel

By patch-clamping the inner mitochondrial membrane, it is concluded that the properties of the current mediated by this novel channel are those of the MCU, enabling high Ca2+ selectivity despite relatively low cytoplasmic Ca 2+ concentrations.
...