Calcium Signaling

@article{Clapham2007CalciumS,
  title={Calcium Signaling},
  author={David E. Clapham},
  journal={Cell},
  year={2007},
  volume={131},
  pages={1047-1058}
}
Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription. 
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