Calcium Signaling

  title={Calcium Signaling},
  author={D. Clapham},
  • D. Clapham
  • Published 2007
  • Medicine
  • Cell
  • Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription. 
    168 Citations

    Figures and Topics from this paper.

    Calcium wave signaling in cancer cells.
    • 135
    • Highly Influenced
    Modulating Calcium Signaling by Protein Design and Analysis of Calcium Binding Proteins
    The machineries, regulation and cellular functions of mitochondrial calcium
    • 141
    Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors.
    • 7
    • PDF
    Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view.
    • 41
    Calcium Sparks in the Heart: Dynamics and Regulation.
    • 14
    • PDF
    MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress.
    • 31
    • PDF
    Calcium Signaling


    Lymphocyte calcium signaling from membrane to nucleus
    • 190
    Capacitative Calcium Entry.
    • J. R. Holda, A. Klishin, M. Sedova, J. Hüser, L. Blatter
    • Medicine, Biology
    • News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
    • 1998
    • 97
    • PDF
    Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.
    • 258
    • PDF
    Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells.
    • 96
    Annexins: linking Ca2+ signalling to membrane dynamics
    • 1,129
    Microdomains of intracellular Ca2+: molecular determinants and functional consequences.
    • 1,015
    Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
    • R. Burgoyne
    • Biology, Medicine
    • Nature Reviews Neuroscience
    • 2007
    • 438
    Redox active calcium ion channels and cell death.
    • P. Waring
    • Chemistry, Medicine
    • Archives of biochemistry and biophysics
    • 2005
    • 179
    ER-mitochondria communication. How privileged?
    • 98
    • PDF
    The molecular choreography of a store-operated calcium channel
    • 476
    • PDF