Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival.

@article{Moore2017CalciumSN,
  title={Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival.},
  author={Lauren M. Moore and Allison Michal England and Barbara E Ehrlich and David L. Rimm},
  journal={Molecular cancer research : MCR},
  year={2017},
  volume={15 7},
  pages={
          942-952
        }
}
Neuronal Calcium Sensor 1 (NCS-1) is a multi-functional Ca2+-binding protein that affects a range of cellular processes beyond those related to neurons. Functional characterization of NCS-1 in neuronal model systems suggests that NCS-1 may influence oncogenic processes. To this end, the biological role of NCS-1 was investigated by altering its endogenous expression in MCF-7 and MB-231 breast cancer cells. Overexpression of NCS-1 resulted in a more aggressive tumor phenotype demonstrated by a… CONTINUE READING