Calcium Induces Expression of Cytoplasmic Gelsolin in SH-SY5Y and HEK-293 Cells

@article{Ji2010CalciumIE,
  title={Calcium Induces Expression of Cytoplasmic Gelsolin in SH-SY5Y and HEK-293 Cells},
  author={Lina Ji and Abha Chauhan and Ved P. S. Chauhan},
  journal={Neurochemical Research},
  year={2010},
  volume={35},
  pages={1075-1082}
}
Gelsolin plays an important role in the regulation of amyloid beta-protein fibrillogenesis. We report here that calcium ionophore A23187 induces the expression of cytoplasmic gelsolin (c-gelsolin), and that protein kinase C (PKC) is involved in the up-regulation of c-gelsolin. In the presence of calcium, both SH-SY5Y and HEK-293 cells upon treatment with A23187 showed an increase in c-gelsolin expression in a concentration-dependent manner. Calcium-mediated up-regulation of c-gelsolin was… CONTINUE READING
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