Calcium-Induced Calcium Release in Smooth Muscle


Calcium-induced calcium release (CICR) has been observed in cardiac myocytes as elementary calcium release events (calcium sparks) associated with the opening of L-type Ca 2 1 channels. In heart cells, a tight coupling between the gating of single L-type Ca 2 1 channels and ryanodine receptors (RYRs) underlies calcium release. Here we demonstrate that L… (More)


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