Calcium: Extracellular calcium sensing and signalling


Ca2+ is well established as an intracellular second messenger. However, the molecular identification of a detector for extracellular Ca2+ — the extracellular calcium-sensing receptor — has opened up the possibility that Ca2+ might also function as a messenger outside cells. Information about the local extracellular Ca2+ concentration is conveyed to the interior of many cell types through this unique G-protein-coupled receptor. Here, we describe new emerging concepts concerning the signalling function of extracellular Ca2+, with particular emphasis on the extracellular calcium-sensing receptor.

DOI: 10.1038/nrm1154

Cite this paper

@article{Hofer2003CalciumEC, title={Calcium: Extracellular calcium sensing and signalling}, author={Aldebaran M . Hofer and Edward Brown}, journal={Nature Reviews Molecular Cell Biology}, year={2003}, volume={4}, pages={530-538} }