Calcium Entry Pathways in Non-excitable Cells

@inproceedings{Rosado2016CalciumEP,
  title={Calcium Entry Pathways in Non-excitable Cells},
  author={Juan Antonio Rosado},
  booktitle={Advances in Experimental Medicine and Biology},
  year={2016}
}
Calcium infl ux is an essential mechanism for the activation of cellular functions both in excitable and non-excitable cells. In non-excitable cells, activation of phospholipase C by occupation of G protein-coupled receptors leads to the generation of inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol (DAG), which, in turn, initiate two Ca 2+ entry pathways: Ca 2+ release from intracellular Ca 2+ stores, signaled by IP 3 , leads to the activation of store-operated Ca 2+ entry (SOCE); on… CONTINUE READING
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