Calcium Dysregulation, IP3 Signaling, and Alzheimer’s Disease

@article{Stutzmann2005CalciumDI,
  title={Calcium Dysregulation, IP3 Signaling, and Alzheimer’s Disease},
  author={Grace E Stutzmann},
  journal={The Neuroscientist},
  year={2005},
  volume={11},
  pages={110 - 115}
}
Ca2+ ions subserve complex signaling roles in neurons, regulating functions ranging from gene transcription to modulation of membrane excitability. Ca2+ ions enter the cytosol from extracellular sources, such as entry through voltage-gated channels, and by liberation from intracellular endoplasmic reticulum (ER) stores through inositol triphosphate (IP3) receptors and/or ryanodine (RyR) receptors. Disruptions of intracellular Ca2+ signaling are proposed to underlie the pathophysiology of… Expand
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