Calcium‐dependent inactivation of the monosynaptic NMDA EPSCs in rat hippocampal neurons in culture

  title={Calcium‐dependent inactivation of the monosynaptic NMDA EPSCs in rat hippocampal neurons in culture},
  author={I. Medina and X. Leinekugel and Y. Ben-Ari},
  journal={European Journal of Neuroscience},
  • I. Medina, X. Leinekugel, Y. Ben-Ari
  • Published 1999
  • Medicine, Biology
  • European Journal of Neuroscience
  • The effects of increased dendritic calcium concentration ([Ca2+]i) induced by single action potentials on monosynaptic glutamatergic excitatory postsynaptic currents (EPSCs) were studied in cultured rat hippocampal neurons. To investigate the respective roles of pre‐ and postsynaptic elements in the depolarization‐induced NMDAR inactivation, we have performed simultaneous paired whole‐cell recordings from monosynaptically connected pre‐ and postsynaptic hippocampal neurons. We report that the… CONTINUE READING
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