Calcium: the Darth Vader of ALS.

  title={Calcium: the Darth Vader of ALS.},
  author={Stanley H. Appel and David R. Beers and L{\'a}szl{\'o} Sikl{\'o}s and J{\'o}zsef I. Engelhardt and Dennis R Mosier},
  journal={Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases},
  volume={2 Suppl 1},
Motor neuron dysfunction and loss in amyotrophic lateral sclerosis (ALS) have been attributed to several different mechanisms, including increased intracellular calcium, glutamate excitotoxicity, oxidative stress and free radical damage, mitochondrial dysfunction, and neurofilament aggregation and dysfunction of transport mechanisms. These alterations are not mutually exclusive, and increased calcium could be a common denominator. Furthermore, the selective vulnerability of spinal motor neurons… CONTINUE READING
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