Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domains

@article{Corneliussen1994CalciumcalmodulinIO,
  title={Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domains},
  author={Brit Corneliussen and Magnus Holm and Yvonne Waltersson and Jacqueline Onions and Bengt Hallberg and Anders P. Thornell and Thomas Grundstr{\"o}m},
  journal={Nature},
  year={1994},
  volume={368},
  pages={760-764}
}
THE ubiquitous Ca2+-binding protein calmodulin (CaM) is a key protein in Ca2+ homeostasis and activation of eukaryotic cells. CaM is the molecular link between free Ca2+ in the cell and the inhibition, or activation, of numerous enzymes. Many nuclear functions are under Ca2+/CaM control, and some transcriptional activators are known to be Ca2+ modulated indirectly through Ca2+/CaM-dependent protein kinases1–4. But Ca2+/CaM has not yet been found to directly modulate any transcription factor or… CONTINUE READING
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