Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.

@article{Li2011CalciumcalmodulindependentPK,
  title={Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.},
  author={Yuwei Li and Molly J. Ahrens and Amy Wu and Jennifer C Liu and Andrew T. Dudley},
  journal={Development},
  year={2011},
  volume={138 2},
  pages={359-70}
}
For tissues that develop throughout embryogenesis and into postnatal life, the generation of differentiated cells to promote tissue growth is at odds with the requirement to maintain the stem cell/progenitor cell population to preserve future growth potential. In the growth plate cartilage, this balance is achieved in part by establishing a proliferative phase that amplifies the number of progenitor cells prior to terminal differentiation into hypertrophic chondrocytes. Here, we show that… CONTINUE READING

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