Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.

@article{SnchezBlzquez2008CalciumcalmodulindependentPK,
  title={Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.},
  author={Pilar S{\'a}nchez-Bl{\'a}zquez and Mar{\'i}a de la Fe Rodr{\'i}guez-Mu{\~n}oz and Carlos Montero and Elena de la Torre-Madrid and J. Rodŕıguez Garz{\'o}n},
  journal={Neuropharmacology},
  year={2008},
  volume={54 2},
  pages={319-30}
}
The long isoform of the phosducin-like protein (PhLPl) is widely expressed in the brain and it is thought to influence G-protein signalling by regulating the activity of Gbetagamma dimers. We show that in the mature nervous system, PhLPl exists as both a 38kDa non-glycosylated isoform and as glycosylated isoforms of about 45, 100 and 150kDa. Additionally, neural PhLPl is subject to serine phosphorylation, which augments upon the activation of Mu-opioid receptors (MORs), as does its association… CONTINUE READING

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