Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5.

@article{Pandey2011CalciumcalmodulindependentKI,
  title={Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5.},
  author={Deepesh R Pandey and Jean-Philippe Gratton and Ruslan Rafikov and Stephen Matthew Black and David Fulton},
  journal={Molecular pharmacology},
  year={2011},
  volume={80 3},
  pages={
          407-15
        }
}
Excessive synthesis of reactive oxygen species contributes to the pathology of many human diseases and originates from changes in the expression and posttranslational regulation of the transmembrane NADPH oxidases (Noxes). Nox5 is a novel Nox isoform whose activity is regulated by intracellular calcium levels. We have reported that the activity and calcium-sensitivity of Nox5 can also be modulated by direct phosphorylation. However, the kinases that phosphorylate Nox5 have not been identified… CONTINUE READING

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