Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress.

@article{Dong2012CalcitriolPR,
  title={Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress.},
  author={Jinghui Dong and Siu Ling Wong and Chi Wai Lau and Hung Kay Lee and C. F. Ng and Lihong Zhang and Xiao-qiang Yao and Zhen Yu Chen and PaulM. Vanhoutte and Yu Huang},
  journal={European heart journal},
  year={2012},
  volume={33 23},
  pages={
          2980-90
        }
}
AIMS The present study investigated whether or not calcitriol, an active form of vitamin D, protects against renovascular dysfunction in hypertension and, if so, whether or not such protection alters the expression of key proteins involved in that dysfunction. METHODS AND RESULTS Changes in isometric tension showed that the impaired endothelium-dependent relaxations in renal arteries of hypertensive patients were enhanced by 12 h in vitro treatment with calcitriol. Dihydroethidium… CONTINUE READING
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