Calcitriol enhances pyrazinamide treatment of murine tuberculosis

  title={Calcitriol enhances pyrazinamide treatment of murine tuberculosis},
  author={Jing Zhang and Ming Guo and Zhi-xiang Huang and Rong Bao and Qian Yu and Ming Dai and Xin Wang and Yan Rao},
  journal={Chinese Medical Journal},
  pages={2089 - 2095}
Abstract Background: Tuberculosis is a leading cause of morbidity and mortality in humans worldwide. There is an urgent need for new and effective drugs to treat tuberculosis and shorten the duration of tuberculosis therapy. 1, 25-dihydroxy vitamin D3 (1,25 (OH)2D3) has been reported to have a synergistic effect with pyrazinamide (PZA) in killing tubercle bacilli in vitro. The addition of 1,25 (OH)2D3 to standard tuberculosis treatment should benefit patients if the adjunctive drug has a… 
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