Calcitriol Protects against the Dopamine‐ and Serotonin‐Depleting Effects of Neurotoxic Doses of Methamphetamine

@article{Cass2006CalcitriolPA,
  title={Calcitriol Protects against the Dopamine‐ and Serotonin‐Depleting Effects of Neurotoxic Doses of Methamphetamine},
  author={Wayne A. Cass and MICHAEL P. SMITH and Laura E. Peters},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1074}
}
  • W. Cass, MICHAEL P. SMITH, L. Peters
  • Published 1 August 2006
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
Abstract:  Repeated methamphetamine (METH) administration to animals can result in long‐lasting decreases in brain dopamine (DA) and serotonin (5‐HT) content. Calcitriol, the active metabolite of vitamin D, has potent effects on brain cells, both in vitro and in vivo, including the ability to upregulate trophic factors and protect against various lesions. The present experiments were designed to examine the ability of calcitriol to protect against METH‐induced reductions in striatal and nucleus… Expand
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  • Chemistry, Medicine
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