Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma

@inproceedings{Uhmann2012CalcitriolIH,
  title={Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma},
  author={Anja Uhmann and Hannah Niemann and B{\'e}r{\'e}nice Lammering and Cornelia Henkel and Ina Hess and Albert Rosenberger and Christian Dullin and Anke Schraepler and Walter J. Schulz-Schaeffer and Heidi Ann Hahn},
  booktitle={Sarcoma},
  year={2012}
}
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Aberrant Hedgehog (Hh) signaling is characteristic of the embryonal subtype (ERMS) and of fusion-negative alveolar RMS. In the mouse, ERMS-like tumors can be induced by mutations in the Hh receptor Patched1 (Ptch). As in humans these tumors show increased Hh pathway activity. Here we demonstrate that the treatment with the active form of vitamin D(3), calcitriol, inhibits Hh signaling and proliferation of murine ERMS in… CONTINUE READING