Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5.

  title={Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5.},
  author={Y. I. Hsu and Henrik Dimke and Joost G. J. Hoenderop and Ren{\'e} J M Bindels},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={25 5},
BACKGROUND Calcitonin (CT) is known to affect renal Ca(2+) handling. However, it remains unclear how CT affects Ca(2+) transport in the distal convolutions. The aim of this study was to investigate the contribution of the renal epithelial Ca(2+) channel, transient receptor potential vanilloid 5 (TRPV5), to renal Ca(2+) handling in response to CT. METHODS C57BL/6 mice received a single overnight (16 hr) injection of CT. In addition, TRPV5 knockout (TRPV5(-/-)) mice and their wild type (TRPV5… CONTINUE READING
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