Calcitonin receptor mRNA is expressed in human medullary thyroid carcinoma.

  title={Calcitonin receptor mRNA is expressed in human medullary thyroid carcinoma.},
  author={Jean-Louis Frendo and R Delage-Mourroux and R{\'e}gis Cohen and Franck Pichaud and Elisabeth Pidoux and J M Guliana and Annick Jullienne},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={8 2},
We recently reported the presence of a truncated form (h-CTR2) of the human calcitonin receptor (CTR) in TT cells, a cell line derived from medullary thyroid carcinoma (MTC). This form (h-CTR2), characterized by the absence of 16 amino acids in the first intracellular domain, was also detected in two cases of MTC. In the present study we determined the expression of CTR mRNA in a larger sample, representative of the different clinical forms of MTC, and in normal thyroid. h-CTR2 was expressed in… CONTINUE READING