Calcitonin messenger RNA encodes multiple polypeptides in a single precursor.

@article{Jacobs1981CalcitoninMR,
  title={Calcitonin messenger RNA encodes multiple polypeptides in a single precursor.},
  author={John William Jacobs and Richard Goodman and William Wei Lim Chin and P C Dee and Joel Francis Habener and Norman H. Bell and John T. Potts},
  journal={Science},
  year={1981},
  volume={213 4506},
  pages={457-9}
}
Recombinant DNA techniques were used to analyze the structure of the messenger RNA encoding a precursor of calcitonin, a small calcium-regulating hormone of 32 amino acids. Analyses of the nucleotide sequences of cloned complementary DNA's comprising the entire coding sequence of the messenger RNA revealed that calcitonin is flanked at both its amino and carboxyl termini by peptide extensions linked to the hormone by short sequences of basic amino acids. The location of glycine next to the… CONTINUE READING

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