Calcitonin gene-related peptide regulates calcium current in heart muscle

  title={Calcitonin gene-related peptide regulates calcium current in heart muscle},
  author={Kageyoshi Ono and Michael Delay and Toshiaki Nakajima and Hiroshi Irisawa and Wayne Giles},
THE influx of Ca2+ due to the transmembrane calcium current, I Ca, has a fundamental role in cardiac pacemaker activity, in the action potential plateau and in excitation-contraction coupling. Both sympathetic and parasympathetic neurotransmitters can modulate I Ca (ref. 1). Recent studies indicate that in both the cardiovascular2-7 and the central nervous systems8,9, nerve varicosities exist that contain a novel non-adrenergic, non-cholinergic peptide—calcitonin gene-related peptide (CGRP)10… CONTINUE READING

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