Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine.

  • Ian M. Bell
  • Published 2014 in Journal of medicinal chemistry

Abstract

Calcitonin gene-related peptide (CGRP) is a potent neuromodulator and vasodilator. It has been implicated in the pathogenesis of migraine by a number of lines of evidence, although its precise role has yet to be fully defined. Compelling evidence for the importance of CGRP in migraine has been provided by clinical trials with multiple small molecule CGRP… (More)
DOI: 10.1021/jm500364u

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