Calcitonin gene-related peptide modulates acid-mediated regulation of somatostatin and gastrin release from rat antrum.

@article{Manela1995CalcitoninGP,
  title={Calcitonin gene-related peptide modulates acid-mediated regulation of somatostatin and gastrin release from rat antrum.},
  author={F D Manela and Jinyu Ren and Jun Gao and J E Mcguigan and Richard F. Harty},
  journal={Gastroenterology},
  year={1995},
  volume={109 3},
  pages={701-6}
}
BACKGROUND & AIMS Acid has been shown to stimulate calcitonin gene-related peptide (CGRP) release from peripheral sensory afferent nerve endings in the stomach. The aim of this study was to determine whether endogenous CGRP was involved, by a neurocrine mechanism, in acid-mediated stimulation of somatostatin and inhibition of gastrin release. METHODS A two-compartment sleeve of antral mucosal/submucosal tissue was perfused to determine sensory nerve and endocrine cell responses to luminal… CONTINUE READING

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