Calcitonin gene-related peptide mediates the cardioprotective effects of rutaecarpine against ischaemia-reperfusion injury in spontaneously hypertensive rats.

@article{Li2009CalcitoninGP,
  title={Calcitonin gene-related peptide mediates the cardioprotective effects of rutaecarpine against ischaemia-reperfusion injury in spontaneously hypertensive rats.},
  author={Dai Li and Xiao-jie Zhang and Lei Chen and Zhichun Yang and Han-wu Deng and June S Peng and Yuan-jian Li},
  journal={Clinical and experimental pharmacology & physiology},
  year={2009},
  volume={36 7},
  pages={
          662-7
        }
}
1. It has been shown that calcitonin gene-related peptide (CGRP) plays an important role in mediating the cardioprotection exerted by rutaecarpine in normal animals. The aim of the present study was to determine whether rutaecarpine is able to decrease the susceptibility of hypertensive animals to ischaemia-reperfusion injury by stimulating CGRP release. 2. Spontaneously hypertensive rats (SHR) were pretreated with rutaecarpine (20 or 40 mg/kg per day, i.g.) for 18 days and then the heart and… CONTINUE READING