Calcitonin gene-related peptide is a depressor of deoxycorticosterone-salt hypertension in the rat.

@article{Supowit1997CalcitoninGP,
  title={Calcitonin gene-related peptide is a depressor of deoxycorticosterone-salt hypertension in the rat.},
  author={Scott C. Supowit and Huawei Zhao and D. Michael Hallman and Donald J Dipette},
  journal={Hypertension},
  year={1997},
  volume={29 4},
  pages={945-50}
}
Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide. We previously demonstrated that neuronal CGRP expression is significantly increased in deoxycorticosterone (DOC)-salt hypertensive rats. To determine the hemodynamic role of CGRP in this setting, we used CGRP8-37, a specific CGRP receptor antagonist. DOC-salt hypertension was induced in Sprague-Dawley rats. To control for DOC pellet implantation, left nephrectomy, and/or saline drinking water, we also studied four… CONTINUE READING

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